Usually, no — burrs are annoying but harmless. However:
They can irritate bare skin.
Some types, like sandburs, have sharper spines that can poke or scratch.
If you are unsure whether what you found is a seed or an insect, look for movement. Burrs will not crawl or shift on their own.
How Do You Remove Them?
Removing burrs can be tedious, but these tricks help:
Use a lint roller or duct tape.
For fabric, gently pull them off one by one.
A fine-tooth comb can help with shoe laces or pet fur.
Wash clothing after removal to get rid of residual barbs.
Burrs are most common in late summer and fall, when plants are releasing their seed pods. Walking through: